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[9005172.] رقم البحث : 9005172 - |
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IMPACT OF INFECTION WITH HELICOBACTER PYLORI ON INTERLEUKIN-10 MRNA EXPRESSION IN STOMACH MUCOSA / تأثير العدوى بالبكتيريا الملوية البوابية على التعبير الجينى للإنترلوكين 10 فى الغشاء المخاطى للمعدة |
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قطاع الدراسات الصيدلية / الميكروبيولوجيا الطبية والمناعة |
| تخصص البحث : الميكروبيولوجيا الطبية والمناعة |
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Bulletin of Pharmaceutical sciences / |
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سارة يوسف محمد ( Sarahyousef30@yahoo.com - ) |
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د/ إبراهيم عبدالهادى أمين - مؤلف رئيسي |
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الميكروبيولوجيا |
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The immuno-regulatory cytokine interleukin 10 (IL-10) is important in reducing the inflammatory response during H. pylori infection. The goal of our study was to explain how H.pylori infection affects mucosal IL-10 mRNA expression. This study included seventy-three patients suffering from gastroduodenal disorders admitted to Assiut University Hospitals, (35 (47.95%) were males, and 38 (52.05%) were females). Three antral biopsies were obtained from each patient during endoscopic examination. Two invasive tests (Rapid urease test (RUT) and polymerase chain reaction (PCR)) were performed for the detection of H. pylori infection in all participants. Real time PCR (RT-PCR) was performed for determination of IL-10 mRNA expression. Results of RUT and PCR indicated that 60.27% of patients were H. pylori infected. Our results showed that patients positive for H. pylori had significantly higher IL10 mRNA expression than H. pylori-negative patients. Finally, overexpression of IL 10 during H. Pylori infection may be implicated in the downregulation of excessive immune response. |
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