الفهرس 
CHAPTER 1: Literature ReviewOnly 14 pages are availabe for public view
 |  | from | 293 |  |  |
| | | from | 293 | | |
Abstract
This comprehensive study is concerned with the intricate sides of nanofluid dynamics through different blood vessels intertwining it with multifaceted aspects of cancer cell. There are many traditional strategies used in cancer therapy such as chemotherapy, hormonal therapy, radiotherapy, and surgical therapy. These therapies pose many side effects on the normal cells. Targeting the drug to the malignant cells is promising idea to reduce the side effects and the drug leakage to the normal cells. The main principle of the target therapy is depending on using the nanoparticles in the process of directing the drug into the tumor cells. Gold nanoparticles proved strong efficiency to deliver and target the drug to reach the affected area with tumors. This occurs by injection the blood by magnetic nanoparticles carrying medical agents and drugs. hyperthermia, magnetic hyperthermia combined with the photothermal therapy are included in this study. The interaction is depending on attracting the injected tumors by ferrometallic gold nanoparticles using transverse magnetic field which causes internal heating and directing a beam of near infrared light from laser to tumors leading an augmenting heat accumulation within cancerous tissue while sparing healthy cells. This study also sheds the light into drug delivery systems, entropy generation, heat transfer, Hall current, and ion-slip effects on the behavior of magnetohydrodynamics flow of nanofluid through porous medium caused by the structure of some tumors through the blood vessels. The main motive force used in this thesis is the peristaltic of the elastic walls of the arteries.
The peristaltic locomotion occurs in tunica media blood vessels and arteries, the bolos pulse through esophagus, and the urine transport in the ureter from kidney towards the bladder. This investigation examines how peristaltic transport and curvature effects of the elastic wave influence the nanoblood flow in the presence of cancer cells, exploring potential therapeutic interventions such as hyperthermia and photothermal therapy. Moreover, the study delves into entropy generation related to energy dissipations during the heating process in this complex flow system. The nanoparticles shapes are very important to enhance the heat transfer process and thermal conductivity of thegold nanoparticles in transferring the heat to the tumors. Many mathematical models have already been investigated by several research workers to explore the nature of blood flow under the influence of an external magnetic field and heat transfer.
Slip and no slip phenomena occurring at the artery walls in blood flow according to some degree of roughness corresponding to walls. In addition, compliant wall properties have received a well concentration amongst latest investigations studying the peristaltic process of bio-fluids.
The fundamentals studies of this thesis is categorized into four parts: the first part concerns with studying heating and slipping effects on gold-blood flow of nanofluid consequent to peristaltic waves with various shape factors in a vertical tube for cancer treatment using perturbation methodology with long wave length and low Reynolds number approximations. The second part is studying the hybrid analysis of magnetism and radiative heating on the nanofluid peristaltic transport with different shapes of ferrometallic gold nanoshells through inclined tube for photothermal cancer therapy. The heat source is included and this represents a case of magnetic hyperthermia interacted with photothermal therapy from thermal radiation. The system of governing equations is solved by using the perturbation analysis with small parameter as series solution. The Hamilton Crosser model for the best thermal conductivity in terms of gold nanoparticles different morphologies is also included. Furthermore, it is worth to analyze the entropy generation during these complex process. The entropy generation is critical phenomena appears in case of thermodynamic and fluid flow applications. The entropy production results in loss of energy due to friction, heat, mixing of fluids, viscosity, magnetic field, and chemical reaction attributed to different processes. As a result, the third part is analyzing the conjugate dissipative radiative heating with thermal slipping and the entropy generation on the peristaltic thrust of MHD ferrometallic gold blood nanofluid with shape factors through compliant resilient tube with curvature effects. The minimization of entropy formation is essential to enhance the performance and the utility of the system in terms of thermal effects and heat conductivity by controlling the external effects. Finally, chemical reactions are impacting the peristaltic flow of nanofluids and changing its viscosity, thermal
conductivity, and heat transfer characteristics. The drug delivery system is related to chemical reaction and drug concentrations which can be dissolved during the flow through the blood. This process through the blood vessels enhances treatment efficacy while minimizing off-target effects. The fourth part is analyzing the influence of thermal radiation and peristaltic thrust on chemical reactions in nanofluid drug delivery via compliant horizontal tube with Hall current and ion slip effects which are deduced from the magnetic flux intensity.