الفهرس 
TitleOnly 14 pages are availabe for public view
 |  | from | 84 |  |  |
| | | from | 84 | | |
Abstract
This study showed the feasibility and safety of using microwave-induced hyperthermia treatment in Hepatic cancer by using microstrip patch antennas with and without nanomaterial.
It’s still difficult to achieve localized hyperthermia treatment without harming surrounding healthy tissues. NPs acting as a microwave absorber in this study to understand localization of heating with microwave radiation which investigated for forestallment harming, hyperthermia treatment, and abnormalities early diagnosis, where NPs can accumulate around or inside tumor regions, in order to help heating localization only on the affecting tumors.
Numerical modelling of NP-assisted thermal therapy can be utilized as a pre-treatment planning tool to forecast the temperature distribution within the body and adjust temperature parameters prior to the specific heating operation, according to recent research. The most fundamental issue in the existing numerical simulation is that the model is frequently assumed to have a basic phantom geometry rather than the actual geometry. One improvement to the current simulation model is the use of three-dimensional (3D) anatomically realistic abdominal model geometry to improve the accuracy of heat transfer for accurate temperature distribution prediction. The use of 3-D realistic abdominal model geometry could be a crucial requirement for accurate temperature distribution prediction during the modelling of the heat transmission process.
A system with a microwave applicator (microstrip patch antenna) at 2.45 GHz, Within the realistic liver tissue model, NPs and two monitors of temperature inside and
Summary and Conclusion
52
outside the malignancy were stimulated to directly explore microwave imaging (MWI) and hyperthermia treatment (HT) for malignant tissues. Simulated findings for SAR values and transitory temperature within normal liver tissue, as well as malignancy, were obtained by using CST studio. Utilizing (BHTE) and comparing the results in two cases with and without NPs. The result had been demonstrated that Ag. NPs can significantly improve in the temperature increase. Yet, the findings were disappointing, and the temperature did not reach to the required level; however, after addition Au. NPs, the temperature is exceeded to 44 °C, attaining the HT without injuring surrounding healthy tissue. An excellent improvement in specific absorption rate (SAR) result when using Au NPs, this technology is suitable for human testing in accordance with European regulations.
Results obtained from our liver simulation showed that:
1. SAR results at frequency 2.45 GHz in the tumor region when using GNPs is about 2 W/kg, while when not using GNPs, the SAR is 0.067 W/kg.
2. Without NPs present around cancer, the temperature inside cancer is 39 ˚C, and outside cancer is 38.5 ˚C at frequency 2.45 GHz.
3. The temperature reaches a value around 44 oC inside the cancer, when using different NPs materials, it reached to a value of 44.3 oC when using Gold NPs and it reached to a value of 42.8 oC when using silver NPs at the identical frequency while the temperature was be around 39 ˚C without using NPs at the same frequency.
from the results of these studies, we can conclude that:
By analyzing the obtained data, it was discovered that AgNPs can significantly improve the temperature increase, but Still, this finding was incorrect; nonetheless, when Au nanoparticles are added, the temperature rises over 44 °C, and the HT is realized at
Summary and Conclusion
53
2.45 GHz without damaging the nearby healthy tissue where it was effected on the tumor only, Gold NPs can also achieve a significant improvement in SAR result.