الفهرس | Only 14 pages are availabe for public view |
Abstract Toxicogenomics is described as a discipline combining expertise in toxicology, genetics, molecular biology, and environmental health to elucidate the response of living organisms to stressful environments. As this emerging field rapidly develops, it is important to assess how toxicogenomic data can be applied to improve risk assessment and provide a means for personalization of medicine. Toxicogenomics encompasses technologies that enable scientists to measure geneticsequence variation (genomics), gene transcription (transcriptomics) protein expression (proteomics), and metabolite profiles (metabolomics) in response to chemicals and other stressors. These ”omics” technologies provide an enormous amount of information that need to be interpreted using bioinformatics tools to better prioritize data and understand a chemical’s progression from the environment to the target tissue within an organism and ultimately to the key steps that trigger an adverse health effect. Toxicogenetics deals with the person himself, it promises to provide the specific polymorphisms responsible for the abnormal reaction of some individuals to certain chemicals. In the near future, through the combined efforts of both toxicogenomics and toxicogenetics, there will be a great breakthrough in the field of medicine, providing a personalized medicine with the best effect and the least side-effect. |