الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitu a group of metabolic di orders characterized
by hyperglycemia and in the majority of long standing patients by
mieroangiopathic a cular complication especially in the eye, kidney
and nervou ystem (G(J~’;ltet at. 2003),
The de elopment 0 type 2 diabere i as ociated with psucreati pcell
dysfunction occurring together with insulin re i ranee. Type 2
manife re 11elf clinically in individual who 10 the ability to produce
. ufficient quantitie of insulin to maintain nonnogl ’cemia in the face of
insulin re istance (Katltl’in-w!aetllel’ et (11.; 2001).
Apoptosi i a mode of progrmnmed cell death. ransdu tion of
apoptotic signals result in.cellular uicide. The Fa i a widely 0 eurring
apoprotic signal receptor molecule expr sed b almost any type ofcells.
It is also relea ed III a oluble circulating form (Fas
(Papathflfff11a sogio« et al., 2000 ((11(/ Co . .onet al., 2005).
e Teml rudies olltyp 2 diabetic patient ha e ound either normal
Or reduced ~-<:ell rna when compared with normal non-diabetic
individual (Sempollx el uf. 2001) .. The mechani m underlying. this
decrease in ~-cell ma s i increased ~-cell apoprosi _ Accumulating
evidence suggests that apoptosis ’is the main form of ~-cell death in type 2
diabete (Butler ef ai., 2003)
Under diabetic condition _ reactive ox)rgen sp ecie (ROS) are
pr duced mainly rhrough the gl cati n reaction. \. hich occur in ariou
tis ues and may play a role ill the development’ of complications in