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Abstract ’:’he r-oLr. of :::ct:11s L: breltst tumours evokes i1’crc’, siJ’{; Lnt.r.i-c nt rei t.h the ndvc nt of nc cur-a t e ,::ethoc1s of dc to c ti: ;illeir concentrations in human t Iaaue s and hiolo~icnl fluids • ’:’11i8 study aimed to compnre the patterns of metal levels L: pvt Lcnt s vzit h bcn Lgn and maliGnant breast tumonro and to detect any deviation from the normal patterns • ””is may be used in (1iaGnosis and prognosis Our :ct’:(~y \’;:0 carried out Itt the departments of ioclle~istry of Faculty of Uedicine , JiChty ;0:”,-,1,es v.o r-e included in this study. ’I’ho y v.e ro cLr.c., :fic into five c:roups ns f oI Lowe : 15 cnSOf: \’.’itil fibronc1enOl:la of the breast. Third 15 Co.80S with fibroadenosis of the breast. Fourt II Gron p: 15 [’’’son \’lith eo.rly breast cancer. -?-i-=-~-t~-_-:-r-o-l-~-~:’ All subjects were submitted to clinical and 1nborntory investicntions • 1l11(Holo{;ical exnmination wns nlso done to pntients with brenst cancer • His t opa t.hol or-Lcu I exami.nn tion wan clone for dLae aae d and n orn.n l 1r-orint tin3UCS • Serum. urine, normal and diseased breast tissues were used for de t cr-ml nn t Lon of the studied ten minern1s. :xtreme care wns taken to prevent contamination during the whole v.o r k by extraneous metals • Sodium and potassium we r-e estinwted us i.ng ”COI1JlIING , 400 ” Fla~ne photometer nccordinc to the method of Hawk, (1965) • 3erum , ur-f re and tissue inorganic phosphorus ViBS nefls,lre d ty ’:lOclified ;;ohenwallner and ’:Timmer method, (1973) 1ieterninnti,ors of calcium, magnesium, iron, copper , zinc , :’lnnr;n.ne3c and lend were done :-~pcctrc,pllot() :-:ctcr • ;”lJ tLc obto.inecl results v.e r e tabulated and stcti,sticnlly 2..C’;alysul • The Lnined cJata revealed (’::..) ContJ:’o’ ~roup : l’ i ’ ,,1’ ,c~._,n_, l’ ::crurn 0lH1 _”il’J_ me tf11 levels in :, Y’CT J1’ t11e 0;”’,:::0 r~,,’;es reported by C,’here ’,”rs n ni;:nificant ,lccre’we of aorum mac.;nesium p.nd iron in pntients with fihroadenoma of the bre aa t , and non nic:nificant chunge s in the levels of other studied metals i;l the oorum • As regards urinary levels of the studied metals, vte fCL’l1dhiC;hly sic;nificant decrease of sodium and pot nes Lurn , whLl.e other studied minerals showed non sic;nificant chnngc s • Concernine; tissue mineraln, we reported a si;::;nific[L~~t Lncr-e nne of disease,’ lu-onnt t.Loeue norl i.um, and highly fJicnificent increase in the concentration of ::!otnsoiU’1 , cr:lciu~:1, magnesium and imrganic phosphorus in ,:iseased breast tissue when compared \’,’ith normal breast tissue • On the other hand, we found a significant decrease of diseased tissue copper and non Gicnificant chanees in the concentrations of other studied eleuents • (C) Fibronclenosis croup: ------------------------- ’There’ ere no: ’.’< [~nificnn t chnrige s 0 f serum levels ~f the stlC~ed mct~ls in pntiellts ~ith fibroadenosis of the h. ’f’ -1[2- Regarc1in:: ul’inGr.~’ level:’ of {.’ potassium in pntients ,’:i t l: fibronc]r’l1osis of the In’2<:13 t , and non siGnificant ch ange s in the other studied minerals • Our re£llllts indicated a hiChly 8iGnificer’~ increase of pota~sium, cnLcLum, r.;n.r~nesiumand inorganic phosphorus in Jisensec: br-o n a t t Lnauc , nr:c1 non significant changes in the concentrations of other studied metGls • (D) Early breast canccr croup : ------------------------------- The caincrl r-e riu Lto nh ov.cd l.h nt. tilC ’C ..-;rtf] n highly siGnificant increase in the serum copper level in patients with enrly brenst cGncer, and there we r’e no ”dc;nificant changes in the levelfl of other studied elements • As regards urinGry levels of th~ 8tudic~ metnls, we found a hiGhly sicnificant dE,cre:’cse of urinary sodium, ann siGnificant decrease of,rir,8ry pot aao tuc- On the other hrm d , there ,,[IS a si;~nificnnt increase of calcium in the urine, IIllile other :ot”died ”retals showed non s:i[jnificant changes of l,ri c levels in patients witll early bren,::t cancer reported [l hiGhly ”iCllific[’ potassium, cnl c i iu. , ::In.{~llCr;]_- and zinc when c o.apru-e d vii and non significant chances in the concentrations of other studied elements • (E) Advnnced br-eoot cancer r~roup : ---------------------------------- The obtained results for miccerals iC’ the C;’ Y’X , cancer were in the sru..o }~[tll:;es obt aLr.e d ;’ p n ti cr: t s wi th early br-eac t cancer • ’l’hc r-enu I t c; ’:’ere a l.ror: t the nnrne bo cnucc metals micht not be nFfecte” 1:’ t h. s t ago of carcinoma of the breast. c’crother possible iritcrpretntioJl is that distnrt DEt88-:~~8CO ~ere not detected or included in the ndvan cc. ,:roup • Conclusion : Based on -thin ntudy, the conCcl1tr~·tions of Dome minerals dI f’To r’ in the cer1Jtn, . r Lnr. nrd 11’C[1[lt tis3ues of pa t l cn t.o y;ith Loni rn nt;~l ’-’Ii. ’;:nnt Y’8nr;t tumours. rrhj_s nay reflect the role of ’-et81s in mnny enz yines nnd the r-cqu Lr-erient of ’~,,,li )’nr’ t cells to more minel’fl 1 c. The cO”11le’ x r-crc t Lons 0 I’ chel fl ti on no y ’llso f : I’Lucn ce the’ n c c umuL. Lion o r (lcp1etion of \r.o, .111,..’,cC”._1’(,1.’” -.,. -!,’]_”n_r, t”l”,(,nA .” J (~_’P. P’’---””’~i.•(lil·’I’,c.-. :()!l t involverl • h..n o t.hor- p onc i b Le rcrl’ctiol~ of i;:l’ 1:1’ :e1y Ln t r’ncc L’Lul nt- Lo oat Lor. of n r.t ur-e of cJ:Lse,:lilc’,; brer:Dt tissues. Adc:itiono.l dat a on rict ul o ii,l breast tumours are essentinl to discover the role of -these elements in t!l€’ pnthO’-:CI-:cfjin of l)re,:-’.st Lumour-n • Further inforrn- .i t i on 111’C :” (~c::s,u’y ’cfo1’o t licy may be used flS |