الفهرس 
Introduction and aim of workOnly 14 pages are availabe for public view
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Abstract
Micro-organisms including bacteria, viruses, fungi and parasites can cause joint and bone diseases. The mechanisms of affection of locomotor system by microorganisms include: Active infection with live organisms [such as septic arthritis]. A reaction induced by inactive or degraded organisms [e.g. Chlamydia and Enterobacteria]. Inflammation induced by auto-activation of the cellular and/ or humoral immune system [e.g. possibly rheumatoid arthritis by EBV]. These mechanisms are not mutually exclusive, for example, Borrelia burgdorferi [which is the cause of lyme disease] can cause infective, reactive and possibly autoimmune arthritis. • The type of arthritis is determined by microbial factors as well as host factors • Infections are common in patients with rheumatic diseases. Reasons for such vulnerability to infection include, immune dysfunction, disease severity, degree of disability, general debility, decreased serum albumin secondary to stimulation of the acute-phase response, reduced nutrition, co-morbid illnesses, and the use of immunosuppressive medications (glucocorticoids, classical DMARDs, and new biologic DMARDs). All of these factors are tightly linked to each other. • Certain infections are more common in rheumatic disease patients, including septic arthritis, cellulitis, respiratory tract infections, and genitourinary tract infections.