الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The nature of the link between angiogenesis and chronic inflammation have been revealed by many recent studies which involves both augmentation of cellular infiltration and proliferation and overlapping roles of regulating growth factors and cytokines. The aim of the present study is to assess blood levels of carcenoembryonic antigen (CEA), carcinogenic antigen 19.9 (CA19.9), vascular endothelial growth factor (VEGF), lipase, and nitric oxide (NO) in colorectal cancer (CRC) patients. Also to evaluate the correlation between the levels of these markers and clinicopathological features of CRC patients; identify the role of the studied markers as prognostic factors of CRC; and evaluate the role of the studied markers in evaluating the efficacy of treatment in CRC patients. This work was intended mainly to evaluate the possible impact of the used chemotherapy in inhibiting angiogenesis. Quantitative detection for CEA, CA19.9, VEGF, lipase and NO levels in peripheral blood of CRC patients have a clinical significance in monitoring development of advanced stage and metastasis. From this study it could be concluded that: CEA, CA19.9, VEGF and NO levels were significantly increased in CRC patients and positively correlated with each other, and with advancing Duke’s stages., Pretreatment serum level of studied markers have an important role in prediction of CRC; advancement and metastasis., CEA has a higher diagnostic sensitivity for advanced CRC,.,CEA followed by NO had the highest diagnostic specificity for advanced CRC.,CA19.9 and VEGF had the highest specificity of metastatic CRC., and Lipase has the lowest sensitivity and specificity as predictor of advancement and metastasis of CRC.