الفهرس 
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Abstract
The thesis is devoted for developing new methods for the analysis of some antidepressant and nocturnal enuresis drugs, namely: sertraline, paroxetine hydrochloride, dothiepin hydrochloride, tolterodine tartrate and oxybutynin hydrochloride, either, in pure forms, in pharmaceutical preparations or in biological fluids. The thesis is divided into five main parts: Part I., a general introduction about antidepressant and nocturnal enuresis drugs is provided Part II. provides spectrophotometric and spectrofluorometric methods for the determination of sertraline and paroxetine hydrochloride in pure form, in pharmaceutical preparations and biological fluids.The proposed methods is based on the reaction of the studied drugs with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) in basic medium. Part III. describes spectrophotometric and spectrofluorometric methods for the determination of dothiepin hydrochloride and tolterodine tartrate using their reaction with eosin. The parameters affecting the reaction were studied. The drugs were also determined in their pharmaceutical preparations. Part IV. Provides a spectrophotometric method for the determination of sertraline and paroxetine hydrochloride. The method is based on the reaction between 2,4-dinitrofluorobenzene and the studied drugs in borate buffer of pH 8.0 and 9.0 for sertraline and paroxetine hydrochloride, respectively. Part V. provides simple and sensitive spectrophotometric and spectrofluorometric methods for the determination of oxybutynin hydrochloride in pure form and pharmaceutical preparations. The method depends on the reaction of the drug with mixed acids anhydrides upon heating at 80C. The methods were additionally applied to content uniformity testing. The validation criteria of the developed methods were intensively studied. All the results were statistically analyzed and compared with those given by official or comparison methods.