الفهرس 
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Abstract
The recent identification of skeletal muscle as an endocrine organ that produces and releases myokines expands our knowledge on how the nervous, endocrine, and immune systems contribute to the maintenance of homeostasis, especially when energy demands are increased. Given the fact that during contraction skeletal muscle cells undergo a major disruption to cellular quiescence, it was hypothesized that muscle cells release a number of biologically active substances that were named myokines, which participate in cell-to-cell and organ-to-organ cross-talk. It is predicted that the myokine field will dominate the coming decade. Muscle-derived IL-6 is released into the circulation in large amounts and works in a hormone-like fashion, exerting its effect on the liver and adipose tissue, thereby contributing to the maintenance of glucose homeostasis during exercise and mediating exercise induced lipolysis. Skeletal muscle has the capacity to produce and express cytokines belonging to distinctly different families. The list includes IL-6, IL-8, IL-15 and LIF. Besides expression of the previous cyokines, skeletal muscles can produce other peptides such as brain-derived neurotrophic factor (BDNF), adiponectin, and follistatin-like 1 which could be classified as myokines.