الفهرس | Only 14 pages are availabe for public view |
Abstract This thesis includes 2 parts: Part I: Phytochemical investigation of the aerial parts of Daucus glaber (Forssk.) Thell. herb belonging to F. Apiaceae. <It includes: 1-The isolation and structural elucidation of a series of new sesquiterpene lactone esters of the guaiane-type named Daucoguaianolide A, B, C, D, E and F, a new sesquiterpene lactone ester of the eudesmane-type named Daucoeudesmanolide A 2-This is the first report for the presence of sesquiterpene lactones within the genus Daucus. 3-The isolation and structural elucidation of a series of new phenylpropanoid esters named Glaberins A, B, C, D and E. 4-This is the first study that establish the relative stereochemistry of a phenylpropanoid ester using X-ray diffraction analysis and the absolute strereochemistry using modified Mosher’s method after chemical modification. 5-Some of the isolated compounds were tested for their cytotoxicity against P-388 murine lymphocytic leukemia cells showing moderate and weak activities. Part II: Phytochemical investigation of the roots of Bryonia cretica L. F. Cucurbitaceae. 1-The isolation and structural elucidation of a new cucurbitane-type triterpene glycoside that was named Bryocreticoside A,2 new isocucurbitacins named isocucurbitacin G and isocucurbitacin H, in addition to the known cucurbitacins G, H, J and isocucurbitacin D. 2-The relative stereochemistry at C-24 was established in the epimers; isocucurbitacin G, H depending on the X-ray diffraction analysis and a correlation between the results of the X-ray diffraction analysis and the 1H and 13C NMR results for the isolated cucurbitacin epimers was established. |