الفهرس | Only 14 pages are availabe for public view |
Abstract NHLs are a collection of lymphoid malignancies with a diverse pathology and natural history. This diversity is illustrated by the different histologics ubtyPesa ndc lassificationosf NHLs that havea ppearedo vert he years. Tumor growth and metastasisa re angiogenesisd ependent’S witching from angiogenesisin hibiting to angiogenesisst imulatingp henotypeu sually accompaniedb y overexpressiono f one or more angiogenicf actors. S-VEGF and S-bFGF are consideredt o be the most endothelialspecific and the most relevant of the known angiogenic growth factors. High pretreatmenlte vel of S-VEGFa nd S-bFGFa re associatedw ith tumor active angiogenesisa nd poor prognosticf actors in relapseda nd/or refractory aggressiveN HLs. s-rc% of patientsw ith aggressiveN HLs donot respold to induction therapya nd 5-15%o f patientsw ith aggressivNe HLs achieveo nly a partial response and 20-40% of relapsed NHLs achieve a second CR after salvage .tte*otttoapy, but l-fieo veratti ”.era:te being 5J0%’ |