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العنوان
Design and synthesis of new sulphur containing heterocyclic compounds of chemotherapeutic interest /
المؤلف
El-Sherbeny, Magda Ahmed.
هيئة الاعداد
باحث / ماجدة أحمد الشربينى
مشرف / على الامام
مشرف / مؤمن يوسف
مشرف / محمد الكرداوى
الموضوع
Chemotherapeutic interest.
تاريخ النشر
1992.
عدد الصفحات
149 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
01/01/1992
مكان الإجازة
جامعة المنصورة - كلية الزراعة - Department of medicinal chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

Several publication were pointed towards the synthesis and antiinflammatory effect of quinazolines and thienopyrimidines.these observations promoted the synthesis of certain novel quinazolines and thienopyrimidines aiming to attain compounds with potent antiinflammatory activity and minimal toxicity.a new series of 4-benzoxazinones was also prepared and the reactions of these benzoxozinones with certain primary and secondary amines were investigated.
Through several chemical reactions are summarized as follows: -
1 - insert group Althenuel in the amino group to of the replaced الانثرانيلك acid then Halqna the composite output by acetic acid anhydride to the nucleus Abannoxazin.
2 - the study of the interaction of Vehicles Abannzuksazan with different amines, such as: 1 - methyl Berazin, n - Secretary-propyl, hydroxy secretary and substituted aniline range Alalecoqssa.
3 - Preparation of the compound 3 - propyl كينازولين the through interaction Vehicles Abannzuksazan with the n - propyl secretary in the presence of Butanol or by Halqna the AV Replaced Abannzamad.
4 - intensify Vehicles Abannzuksazan with the hydrazine hydride in different conditions to produce either benzoic acid derivatives of maleic open-chain or cyclic Elkinasulan derivatives.
5 - Interaction 2 - (20 Tinil) -6 - chloro -4 -1.3 hand - Bnozaksazan -4 - Online with anhydrous ammonium acetate at a temperature of 200 Mthwaih given of my parents Hedrukinazulan derivatives -4 - Online.