الفهرس 
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Abstract
This study comprised fifty-six balb-C mice (8-10 weeks old). Four mice were sacrificed immediately for collection of unwounded skin specimens. Fifty two mice were divided into two group: Group I, includes twenty-eight mice in which animals‘ backs were shaved by an electric clippers and two dorsal wounds made on each side of the midline and at the a sighned times, wounds were excised. Standard haematoxylin and eosin staining was performed in all wounds for studying of epidermal wound healing. Peroxidase immuno-histochemistry techniques were used for localization of PKC isoenzymes: ?, ?1 and ?. In addition to desmosomes from the first day after wounding to the seventh day. Group II which is a Pilot experiment used to study the effect of stimulation and inhibition of PKC during wound healing. Aim of the work examine the involvement of the PKC isoforms during the process of epidermal wound healing and investigate the effect of PKC? stimulation and /or depression on the process of epidermal wound healing. Results ” In epidermal wound healing in balb C mice, cells at the wound edge proliferate and migrate to the denuded wound gap to fill it completely by the sixth day after wounding and restoration of the skin homeostasis starts after complete healing of the wound. ” Desmosomes between cells of the epidermis are disrupted by wounding with internalization of them within cells at the wound edge. ” (PKC?) and (PKC?1) are localized mainly to the inner layers of the epidermis during the process of wound healing but disappear completely by the sixth day. ” (PKC?) is localized mainly to the inner layers of the epidermis at the beginning and by the end of wound healing. ” Local application of TPA (PKC stimulant) to epidermal wounds in balb C mice help in rapid healing while Local application of G?6976 (PKC inhibitor) may delay this healing. Summary and Conclusion ” PKC? may help in proliferation and migration of cells across the wound. (PKC?1) may share in modulation of intercellular adhesions to allow migration of cells. (PKC?) may play a role in restoration of the skin homeostasis by its apoptotic activity. Local application of TPA (PKC stimulant) to epidermal wounds in balb C mice help in rapid healing while Local application of G?6976 (PKC inhibitor) may delay this healing.