الفهرس 
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Abstract
In the present investigation, new series of 3substituted 5(4piperazin1yl) 1,2,4triazolo[4,3c]quinazolines, 2(4phenylpiperazin1yl)4benzotriazepinoquin azoline and phenylpiperazinylimidazo [2<U+2019>,1<U+2019>:5,1]1,2,4triazolo [4,3 c ]quinazoline systems have been prepared aiming to attain potent serotonergic agents.The structures of these compounds were determined by elemental microanalysis and 1HNMR. Some of them were studied by IR, and mass spectroscopy. All the newly synthesized compounds, except compound 120, were subjected to in vitro screening for serotonergic activity using isolated pulmonary arterial rings of rat. The results showed that most of the compounds under test exhibited different degrees of response described as compounds capacity to inhibit pulmonary rat arterial ring contraction caused by serotonin. Eleven compounds were proved to act as serotonergic antagonists.