الفهرس 
Liver cirrhosisOnly 14 pages are availabe for public view
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Abstract
The present study was conducted on 40 subjects, divided into 3 groups; HCC, LC and controls. The patients groups were selected from inpatients of Gastroenterology Centre and Internal Medicine Departments of Mansoura University Hospital. of the cancer or liver cirrhosis patients had other liver diseases or other associated diseases that may affect the assessment of the serum trace elements levels. group I included 10 patients with recently discovered HCC (4 males and 6 females) had mean age of 52.8(R+(B7.7 years. group II included 20 patients with liver cirrhosis (8 males and 12 females) had mean age of 49.3(R+(B7.7 years. LC group was further subdivided into two subgroups, compensated and decompensated liver cirrhosis according to development of complications such as hepatic encephalopathy and esophageal bleeding. group III included 10 healthy subjects (6 males and 4 females) and were studied as a control group. They were age (49(R+(B6.8 years) and sex matched with patients group. Blood samples were collected from all subjects (patients and controls) for assessment of liver function tests, complete blood picture, serum creatinine, serum AFP and serum levels of Cu, Zn and Mg. The recorded results showed: Serum level of Cu was significantly higher (P<0.01) in patients with HCC than the control group, but it was insignificantly higher in LC group as compared to controls. While serum Zn was significantly lower in both HCC (P<0.05) and LC patients (P<0.01) as compared to controls. In addition, it was insignificantly lower in DLC (74.2(R+(B31 <U+00B5>g/dl) than CLC groups (112.6(R+(B38.6 <U+00B5>g/dl). Both Cu and Zn serum levels showed no significant differences between HCC and LC patients. In patients with LC, decreased serum Zn level and increased Cu/Zn ratio were found to have significant correlations with worsening of ChildPugh classification (P<0.01, P=0.05 respectively). Moreover, Cu/Zn ratio was found to be significantly higher in HCC, CLC and DLC (P<0.001, P=0.001 and P<0.01 respectively) compared to controls, but there was no significant difference in HCC compared to LC patients. There was a significant positive correlation between serum Cu and Zn in both HCC and LC groups (P<0.01 and P<0.05 respectively). On the other hand, serum Mg was significantly lower in HCC (P<0.05) and in LC (P=0.001) compared to controls. It was also significantly lower in CLC and DLC ((P<0.05 and P<0.01 respectively) compared to controls, but there was no significant difference of serum Mg either between HCC and LC or CLC and DLC patients. In the present study, a significant negative correlation was found between serum Mg and both ALT and AST (P=0.01, P<0.05 respectively) in the control group. While serum Zn was found to have significant negative correlation with ALT (P<0.05). In the HCC and LC groups, significant positive correlations were seen between serum Cu and serum total protein (P<0.05, P<0.01); while in LC patients, a significant positive correlation was found between serum albumin and both serum Cu and Zn (P<0.01). Conclusions: There is elevation of serum Cu level in patients with liver disease (HCC & LC). Hypozincaemia is a feature of chronic liver diseases and is more advanced in decompensated cirrhosis. High Cu/Zn ratio is found but it has no differentiating value between malignant & cirrhotic patients. Hypozincaemia & high Cu/Zn ratio are significantly correlated with worsening of ChildPugh classification of LC patients. Hypomagnesaemia is found in hepatic patients (HCC & LC).