الفهرس 
Hyoscyamus muticusOnly 14 pages are availabe for public view
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Abstract
The present work was undertaken to investigate the following: Examination of Aspergillus fumigatus isolate for gliotoxin producing ability, determination of the optimum conditions for gliotoxin production, studying the method of extraction, purification, qualitative and quantitative determination of the compound, and biological studies on the product to test its biological clinical characteristics.The results obtained are summarized as follows: Examination of Aspergillus fumigatus isolates to select the best isolate which produces gliotoxin Aspergillus fumigatus (NRC 129) and A. fumigatus (NRC 147) have proved to be the most active producers of gliotoxin. The two isolates were tested for gliotoxin production using different fermentation medium, CzapekDoxwheat, CzapekDoxrice extract and CzapekDoxcrushed rice at different incubation period. ?The results obtained indicated that A. fumigatus (NRC 147) is the best isolate for gliotoxin production and Czapek Doxrice extract medium is the best medium for the production of gliotoxinStudy of some factors affecting gliotoxin production:Experiments were performed to find out the optimum environmental conditions and nutritional requirements for maximum yield of gliotoxin by A. fumigatus (NRC 147) these include:Environmental factors Gliotoxin production increased gradually by increasing incubation period and its maximum amount (362.4 mg/l) was recorded after 5 days.