الفهرس 
Index of abbreviations
PathologyOnly 14 pages are availabe for public view
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Abstract
In the past, most soft tissue sarcomas of the extremities were treated by local resection or amputation. However, the local recurrence rate was high and many patients died from distant metastases. Attempts have been made to salvage limbs by the initial use of chemotherapy and radiotherapy to reduce the size of the tumor and to allow local control by local surgical excision rather than by amputation. Application of such a simplified and low cost method of preoperative intraarterial tourniquet injection of doxorubicin with preoperative external beam radiotherapy then wide surgical excision followed by postoperative systemic chemotherapy introduced by our Surgical Oncology Unit, Oncology Center- Mansoura University, and the assessment of the procedure as a new treatment option for patients with soft tissue sarcoma in extremities was the primary aim of our work. NO procedure related complications were reported in our study. The toxicity of the intra-arterial injection of Adriamycin among was much less than those who received systemic chemotherapy. The complications of preoperative external radiotherapy were much less than those patients who received postoperative external radiotherapy. Our study found that a combination of preoperative doxorubicin, radiotherapy, and surgery not involve a high risk of wound healing problems. In our study patients showed no local recurrence and better disease - free survival. Also they showed good overall survival during the period of study. But the follow-up period of these patients (up to 12 months) doesn’t appear to be sufficient. Based on these results, we recommend that preoperative intraarterial tourniquet injection of doxorubicin with preoperative external radiotherapy then wide surgical excision can be applied in patients with soft tissue sarcoma of extremities as a limb salvage method achieving a better survival, less complications, and a better life style