الفهرس 
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Abstract
Background: Cardiac affection in multisystem inflammatory syndrome in children (MIS-C) occurs in ∼80% of patients. Left ventricular (LV) systolic dysfunction is the most frequent finding.
Methods: In this prospective cohort study, we report assessment of LV function and cardiac injury in 22 MIS-C patients using Cardiac biomarkers and Speckle Tracking Echocardiography. We compare those patients at initial presentation and at 3 months follow up.
Results: Among 22 MIS-C patient cardiac biomarkers (cardiac troponin and creatinine –kinase mb) showed highly statistically significant regression on comparing their values at initial presentation and after 10 days follow up. Ejection fraction was impaired in 43.7%, with a mean value of 52.3% (Range: 32% to 69%). Patients with abnormal strain had a lower EF, more organ systems involvement and were more likely to require inotropic support. Lower peak longitudinal strain rates were detected in 59% of MIS-C patients at initial presentation in comparison to follow up assessment 3 months later. Patients with initially depressed function, EF normalized in 21 of 22 patient (95.4%), but 5 of 22 (18.1%) of patients had persistently abnormal systolic strain at 3 months follow up.
Conclusion: LV systolic dysfunction is common in the acute phase of MIS-C, and detection may be improved with strain imaging. Longitudinal cardiac follow-up is imperative, as patients may be at risk for persistent LV dysfunction.