الفهرس 
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Abstract
Background:
Genital wart is a highly infectious sexually transmitted disease caused by the human papillomavirus, Warts are considered benign tumors involving skin and mucous membrane caused by human papillomavirus (HPV). Survivin is one of the apoptosis inhibitor proteins, responsible for apoptosis suppression and cell cycle regulation. There are lack of studies evaluating serum and tissue survivin in genital warts and their correlation with disease severity.
Aim and objectives: The aim of this study was to measure the expression level of survivin gene in tissues and its protein level in serum of genital wart patients to highlight its possible role in the pathogenesis and to improve the management of this common skin disease.
Subjects and Methods: This was a cross sectional study. Patients was recruited from the dermatology outpatient clinic and andrology, infertility and sexually transmitted diseases outpatient clinic of the Suez Canal University Hospitals, Ismailia. The study included two groups 30 patients with genital wart and 30 healthy age and gender matched controls. Detailed history and full examination were taken then we performed investigations to assess survivin protein level in serum of both groups using enzyme-linked immunosorbent assay (ELISA) and survivin gene expression in tissues and serum of the diseased group using real time polymerase chain reaction (PCR).
Results: There was a statistically significant relation between patients with genital wart and control group in expression level of survivin gene in lesional tissue, expression level of survivin gene in serum and its serum protein level with p value of 0.001.
Conclusion: over-expression and excessive of survivin gene found in genital wart tissues and serum with high serum level of its protein supports the view that this immunomodulator and apoptosis inhibitor molecule may play a role in the pathogenesis and severity of the disease.
Keywords:
Survivin, Genital Warts, Apoptosis.