الفهرس 
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Abstract
Background: Psoriasis is a cutaneous disorder characterized by epidermal hyperproliferation and inflammation with a marked infiltration of T cells, neutrophils, and macrophages. Psoriatic inflammation was once considered to be mediated by T-helper 1 (Th1) cells; however, recent studies increasingly indicate that immune responses by newly characterized Th17 cells are also involved in the pathogenesis of psoriasis.
Aim: The aim of this work was to study the influence of UVB on the serum level of P19 subunit of IL-23 in patients with psoriasis.
Patients and methods: This quasi-experimental study was conducted on 30 patients who have psoriasis and were recruited from the dermatology outpatient clinic of the Suez Canal University Hospitals, Ismailia. All patients were subjected to detailed history taking and general and dermatological clinical examination. At the baseline and one week after the end of the treatment (at week 12), blood samples were taken to evaluate P19 subunit of IL-23 level and a blind clinical assessment by calculating PASI score was made. The PASI score evaluates the severity of psoriasis in relation to three parameters: E, erythema; I, infiltration; and D, desquamation.
Results: In our study, 24(80%) of patients were male and 6(20%) patients were female. The mean ± SD of age of patients is 33.27 ± 10.27 years (range 19-45). Patients had mean P19 subunit of IL-23 of (521.23±199.27) pg/ml before treatment and (241.16±187.16) pg/ml after treatment with statistical significant difference (p<0.001). Patients had mean PASI score of (14.33±4.24) before treatment and (8.12±3.07) after treatment with statistical significant difference (p<0.001). Mean P19 subunit of IL-23 level had significant direct moderate correlations with duration of the disease and PASI score (r=0.538 and 0.662, p=0.002 and <0.001, respectively).