الفهرس 
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Abstract
The burden of cancer incidence and mortality is rapidly growing worldwide due to the distribution of the main risk factors for cancer, which are associated with socioeconomic development. The treatment of cancer has been a highly complex process. Chemotherapy is considered the most effective and widely used modality in treating several types of cancers as used alone or in combination with radiotherapy, however, they cause numerous side effects due to increasing the oxidative stress agents and consequently led to toxicity of vital organs. Combination therapy of anticancer agents enhances efficacy compared to the mono-therapy approach because it targets key pathways in a characteristically synergistic or an additive manner. Leukemia can be classified as acute or chronic based on the rapidity of proliferation and myeloid or lymphoid based on the cell of origin. Predominant subtypes are acute myeloid leukemia and chronic myeloid leukemia, involving the myeloid lineage; acute lymphoblastic leukemia; and chronic lymphocytic leukemia.