الفهرس | Only 14 pages are availabe for public view |
Abstract This case-control comprehensive study aimed to enhance our understanding of Hashimoto’s thyroiditis (HT); an autoimmune thyroid disorder characterized by chronic inflammation of the thyroid gland. 100 HT patients and an age and sex-matched control group of 100 healthy individuals were extensively examined in terms of demographic, clinical, biochemical, genetic, and immunological parameters. Key findings from this study include: • Gender Bias: HT exhibited a significant gender bias, with a higher prevalence in females, aligning with previous research highlighting the vulnerability of women to autoimmune thyroid disorders. • Clinical Manifestations: Clinical symptoms such as expressionlessness and oral/genital ulcers were highly prevalent among HT patients, underscoring the diverse clinical presentations of the disease. • Biochemical Aberrations: Several biochemical parameters showed significant differences between HT patients and controls, suggesting the systemic impact of HT on various organ systems. • Thyroid Function and Antibodies: Thyroid function tests and thyroid antibodies demonstrated highly significant differences, confirming the presence of thyroid dysfunction and autoimmune processes in HT patients. • Genetic Markers: Gene expression analysis identified significant differences in ERN1 and EYA1, suggesting their potential role in the pathogenesis of HT. |