الفهرس | Only 14 pages are availabe for public view |
Abstract Coronary artery ectasia (CAE) was defined as dilation of >1.5 times the normal adjacent segments of the vessel. Medical management for CAE is a controversial area as there is lack of evidence-based medicine. Aim: We sought to study efficacy and safety of dual-antiplatelet therapy (DAPT) versus oral anticoagulant (OAC) in patients with isolated and non-obstructive atherosclerotic CAE, as well as predictors of outcome. As a secondary aim we studied possible predictors of ectasia among these patients Methods: We prospectively enrolled 79 patients diagnosed on elective coronary angiography to have either isolated CAE or non-obstructive atherosclerotic CAE. A corresponding number of patients with normal coronaries recruited within the same time interval were comparatively studied as a control group. Included patients with CAE were assigned in a 1:1 pattern to receive either DAPT (aspirin plus clopidogrel) or an OAC (warfarin). Demographic, clinical, laboratory, and angiographic data of patients with CAE were examined. Follow up was performed at 3-month, 6-month and 9-month intervals for efficacy endpoints with occurrence of one or more major adverse cardiac events (MACE) and safety endpoints with occurrence of either major or minor bleeding. |