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Abstract The aim of the current study is studying the efficacy of using autologous platelet rich fibrin with myringoplasty for closure of tympanic membrane perforation preventing graft displacement, promoting quicker healing and preventing complications. The current study included 100 patients 41 males (41%) and 59 females (59%), The age of the patients in study group ranged from 19 to 40 years with a mean age of 31.04 years while in the control group age of patients ranged from 15 to 45 years and a mean of 32.24 ±years, who were admitted to the Department of otorhinolaryngology of Menofeya University Hospital, and Shebin Elkom Teaching Hospital The patients were divided into two groups: group A, 50 patients, 21 patients were males (42%) and 29 patients were females (58%), age ranged from 19 to 40 years with a mean (± SD) of 31.04 ± 6.74 years, , in this group PRF was used with myringoplasty by adding it to the graft. group B, 50 patients, 20 patients were males (40%) and 30 patients were females (60%), age ranged from 19 to 45 years with a mean (± SD) of 32.24 ± 7.39 years, PRF wasn’t used with myringoplasty. The current study revealed the following results: Regarding age, sex, size of perforation, preoperative haemoglobin concentration, platelet count, and size of tympanic membrane perforation, there is no statistically significant difference (p value >0.05). There is statistically significant difference in the results of tympanic membrane graft uptake between the two groups (p value ˂ 0.05). There is statistically significant difference in between post-operative air bone gap after 6 months between 2 groups. Regarding hearing gain, there is statistically significant difference between 2 groups. Regarding relation between size of the tympanic membrane perforation and graft uptake, there is no significant difference statistically between 2 studied groups. Regarding time consumed during operation, and postoperative complications, there is no significant difference statistically between 2 studied groups. |