الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 156 |  |  |
| | | from | 156 | | |
Abstract
Multiple sclerosis (MS) is a chronic disease of the central nervous system affecting approximately 2.5 million people worldwide. It is one of the most common neurological disorders and represents the leading cause of non-traumatic disability among young adults.
The main histopathological features are demyelination and neurodegeneration, whereas the exact etiology and pathogenesis remain not completely understood
Cerebrovascular hemodynamic insufficiency in MS may have clinical implications. The impairment of vasomotor response can be the functional substrate that joins with structural damage and contributes to MS symptomatology. Indeed, reduced perfusion reserve can translate into inadequate blood supply when metabolic demand is increased by the activation of cerebral areas, as during cognitive tasks.
Interestingly, epidemiological data showed that patients with MS are at higher risk of stroke and CVR impairment increases the hazard of cerebral ischemic events: the assessment of cerebral hemodynamic status can, hence, potentially represent a simple para-clinical tool to stratify individual vascular risk
Aim of study:
To evaluate cerebrovascular changes in patients with MS by TCD, and to study the impact of cerebrovascular changes on disease progression, physical disability and cognitive impairment of MS patients.
Patients and methods:
The present cross sectional, hospital-based study was carried out at the Neurology unit of the department of Neurology and Psychiatry, Assiut University Hospitals.