الفهرس | Only 14 pages are availabe for public view |
Abstract Rheumatoid arthritis is a chronic inflammatory disease that leads to bone and cartilage destruction and extra-articular complications, including atherosclerotic vascular disease and premature mortality. The receptor for advanced glycation end products (RAGE) has been implicated in the pathogenesis of RA through its ability to amplify inflammatory pathways. RAGE, is a member of the immunoglobulin super family, encoded in the Class III region of the major histocompatibility complex. It has previously been shown that a polymorphism of the gene encoding RAGE located within the V-type immunoglobulin domain of RAGE, which results in a glycine to serine substitution at amino acid position 82, is in linkage disequilibrium with HLA-DR4, it was therefore not surprising that the Ser82 allele was increased in RA subjects. The aim of the present study was to detect RAGE gene polymorphism (G82S) in rheumatoid arthritis patients, to assess its role as a risk factor of the disease and to assess the relation between RAGE gene polymorphism (G82S) and rheumatoid arthritis complications. This case control study was carried out at Clinical Pathology Department, and Rheumatology and Rehabilitation Department, Zagazig University Hospitals on 30 subjects. |