الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
.Surgical excision of brain tumors is often complicated by significant blood loss. Major intraoperative blood loss may lead to life-threatening hemodynamic instability requiring massive transfusion of crystalloids, colloids and allogeneic blood.Brain tumors produce tissue plasminogen activator and tissue factor, which may lead to significant changes in fibrinolytic parameters and hyperfibrinolysis. In addition, molecules on the tumor surface could activate the coagulation cascade through non specific tissue thromboplastin.Tranexamic acid potential to reduce perioperative blood loss has been proven in a variety of surgical procedures However, in the field of neurosurgery, its use is mostly limited to spinal and extracranial surgery