الفهرس 
EARLY ONSET NEONATAL SEPSISOnly 14 pages are availabe for public view
 |  | from | 139 |  |  |
| | | from | 139 | | |
Abstract
ABSTRACT
Background: Early-onset sepsis (EOS) remains a common and serious problem in neonates.
The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are easily accessible biomarkers that have been reported to have meaningful correlations with inflammatory markers.
Objectives: We aimed to evaluate the NLR, PLR and SII as a diagnostic tests for early detection of EOS.
Patients and Methods: This study was carried out on 100 preterm infants at the Neonatal Intensive Care Unit (NICU) of Ain Shams University children’s Hospital. They were divided into two groups: group A (patient group) which included 45 preterm, suffering from EOS and group B (controls group) which included 55 healthy preterm. History-taking, complete clinical examination, blood culture, complete blood count (CBC), C-reactive protein (CRP), NLR, PLR and SII were done.
Results: Patients group (high CRP, Rodwell Score positive, positive blood cultures) had significantly higher NLR, PLR, and SII at first and third day of life compared with the controls group(negative CRP, Rodwell Score non sepsis and negative blood cultures). NLR of 1.9 was determined as the predictive cutoff value of EOS (sensitivity 91.11%; specificity 92.73%). A PLR of 53.79 was determined as the predictive cutoff value of neonatal EOS (sensitivity 93.33%; specificity 43.64%). A SII of 333.97 was determined as the predictive cutoff value of neonatal EOS (sensitivity 97.98%; specificity 90.91%).
Conclusion: NLR, PLR and SII had high sensitivity and specificity as diagnostic markers for early-onset neonatal sepsis.