الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Patients with MS may have elevated sympathetic activity as a measure of the disease’s severity. For many MS patients with symptoms, PMBC is the standard of care. We aimed to show the effects of PMBC on ANS activity in the MS patients by HRV analysis and its correlation with clinical, neurohormonal and hemodynamic variables.
Fifty two patients with severe MS and sinus rhythm who underwent successful PMBC and thirty healthy individuals matched for age and gender as a control group were enrolled.
Apart from significant haemodynamic improvements, mean HR, LF (day and night), LF/HF (day and night) significantly decreased and SDNN, RMSSD, PNN50, HF (day and night) significantly increased in the early period after PMBC and these changes were preserved for up to one month. Also, NT pro-BNP levels were significantly decreased in MS patients after successful PMBC. There was significant positive correlation between some HRV variables (mean HR, LF (day and night) and LF/HF (day and night) and hemodynamic and echocardiographic variables such as LA pressure, LA diameter and PASP before PMBC and this correlation was maintained after PMBC. Also, there was significant positive correlation between some HRV variables (mean HR, LF (day and night) and LF/HF (day and night) and NT pro-BNP before PMBC and this correlation was maintained after PMBC. Moreover, there was significant positive correlation between NT pro-BNP and LA pressure, LA diameter and PASP before and after PMBC. In addition to, there was significant positive correlation between the severity of dyspnea and both HRV parameters (mean HR, LF (day and night) and LF/HF (day and night)) and NT pro-BNP before PMBC, and improvemet of dyspnea was associated with their decrease after PMBC.