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العنوان
Chemical Investigation and Biological Assessment of Chemical Constituents from Some Promising Natural Sources /
المؤلف
Hal, Dina Mohamed Mohamed Mahmoud.
هيئة الاعداد
باحث / Dina Mohamed Mohamed Mahmoud Hal
مشرف / Jihan M. Badr
مشرف / Amany K. Ibrahim
مشرف / Enas E. Eltamany
مشرف / Reda F. A. Abdelhameed
الموضوع
prostate - cancer. Saponins. Cytotoxic drugs. antioxidant.
تاريخ النشر
2023.
عدد الصفحات
333 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
11/9/2023
مكان الإجازة
جامعة قناة السويس - كلية الصيدلة - العقاقير
الفهرس
Only 14 pages are availabe for public view

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Abstract

Phytochemical study of the aerial parts and roots of the plant Zygophyllum album led to the isolation and identification of eleven metabolites, two new saponins (Zygo-albuside A (7) and Zygo-albuside D (9)) along with nine known compounds. The total phenolic and flavonoid content, in addition to the antioxidant activity, of the crude extracts were investigated, where the aerial parts revealed a higher value overall. Moreover, the biosynthesis of AgNPs utilizing the crude extract of the arial parts and root of Z. album L. and the phenolic extracts was achieved to enhance the cytotoxicity of the different plant extracts. Aerial and roots crude extracts along with roots extract isolated compounds showed promising In vitro cytotoxicity against lung and prostate cancer cell lines. Aerial parts extract and two isolated compounds (compound 7 & 8) exhibited promising in vivo protective antioxidant activity against testicular damage induced by Methotrexate.
Key words: Zygophyllum album, Saponins, cytotoxic, antioxidant, lung cancer, prostate cancer.