الفهرس | Only 14 pages are availabe for public view |
Abstract Phytochemical study of the aerial parts and roots of the plant Zygophyllum album led to the isolation and identification of eleven metabolites, two new saponins (Zygo-albuside A (7) and Zygo-albuside D (9)) along with nine known compounds. The total phenolic and flavonoid content, in addition to the antioxidant activity, of the crude extracts were investigated, where the aerial parts revealed a higher value overall. Moreover, the biosynthesis of AgNPs utilizing the crude extract of the arial parts and root of Z. album L. and the phenolic extracts was achieved to enhance the cytotoxicity of the different plant extracts. Aerial and roots crude extracts along with roots extract isolated compounds showed promising In vitro cytotoxicity against lung and prostate cancer cell lines. Aerial parts extract and two isolated compounds (compound 7 & 8) exhibited promising in vivo protective antioxidant activity against testicular damage induced by Methotrexate. Key words: Zygophyllum album, Saponins, cytotoxic, antioxidant, lung cancer, prostate cancer. |