الفهرس 
Chapter 1: IntroductionOnly 14 pages are availabe for public view
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Abstract
Hydrazones and their metal complexes have attracted considerable
attention due to their great biological activity. The use of several hydrazone
derivatives in drug synthesis has resulted in extensive research on the
chemistry and metabolism of these drugs. It was found that some azo and
hydrazo groups confer antineoplastic, antibacterial, antifibrotic and antiviral
properties.
This thesis consists of three main chapters:
Chapter 1: Introduction
This chapter gives a literature survey about the coordination chemistry,
definition of hydrazine and hydrazone compounds and their importance. In
this chapter, the definition of the liver fibrosis and the mechanism of CCl4 in
liver fibrosis are presented. We concentrated about the analytical and
biological applications of hydrazones and their metal complexes by
presented some published research of them.
Chapter 2: Experimental
This chapter presented a brief description for the methods of synthesis
of the N-[(1E)-1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)ethylidene]-2-
(4-methylanilino)acetohydrazide (HL) and its metal complexes. The
hydrazide was prepared by the condensation of ethyl chloro acetate with 4-
methyl aniline, then the acetate product reacted with hydrazine hydrate then
the product reacted with dehydroacetic acd to form N-[(1E)-1-(4-hydroxy-6-
methyl-2-oxo-2H-pyran-3-yl)ethylidene]-2-(4-methylanilino)acetohydrazide
(HL). The prepared ligand reacted with metal salts of copper(II), cobalt(II)
and manganese(II) to form metal complexes.