الفهرس | Only 14 pages are availabe for public view |
Abstract was no significant difference of mean EF, FS & AO/LA ratio before and after treatment. Two cases had impaired EF at baseline and after treatment EF became normal. Conclusion: OI had variable pathologic cardiac effects as aortic root enlargement, left atrial enlargement and two cases of impaired left ventricular ejection fraction at baseline that became normal after treatment. Otherwise, OI was not reported to have a significant effect apparently on intraventricular septum and left ventricular volumetric parameters in systole or diastole. Bisphosphonate therapy had a significant effect on the score of aortic root and ejection fraction (which improved significantly). However, treatment with bisphosphonates could not protect against the progressive effects of OI on cardiac muscle with time as the percentage of patients with impaired left ventricular volumetric parameters in systole or diastole increased significantly during follow-up. The most common pulmonary disease in OI children was the restrictive pattern and it could be explained by the skeletal deformities of the chest wall and spine |