الفهرس | Only 14 pages are availabe for public view |
Abstract English Summary This work is composed of aim of the work and three main chapters Aim of the work The work aimed to prepare and characterize new aspirin metal complexes to study their biological activity against bacteria and fungi hoping to explore some effective compounds to be used in treatment of some microbial diseases. I- Introduction This chapter includes an overview of previous researches for ligand metal complexes and their applications. II- Experimental This chapter contains the chemical and instruments used in Practical part of thesis as follow: 1) Preparation of the ligand and its metal complexes. 2) Characterization of the ligand and its complexes using: • Physical techniques such as molar conductance, magnetic susceptibility and melting point. • Elemental analyses (C, H, N, Cl and M). • Spectral techniques as IR, UV-Vis., 1HNMR, mass spectra and ESR measurements. • Thermal techniques as DTA and TGA 3) Measurement of Antibiological activity. III- Results and discussion This chapter includes characterization of the ligand and its metal complexes. The complexes were prepared and characterized by elemental analyses, IR, UV-Vis spectra, Magnetic moments, Conductivity, 1H-NMR and Mass spectra, Thermal analyses (DTA and TGA) and ESR measurements. The elemental analyses, spectral data reveal that, the formed complexes are colored, stable in the air and soluble in solvents such as DMF, DMSO and ethanol. The antibacterial activity was tested against two bacterial strains; Gram-positive Staphylococcus aureus as well as Gram-negative Escherichia coli strains. The complexes were also subjected to antifungal activity against Aspergillus flavus and Candida albicans. Complex (10) and complex (25) appeared in nano size and shows high activity against bacteria and fungi. |