الفهرس | Only 14 pages are availabe for public view |
Abstract -41- SUMMARY & CONCLUSION It has long been observed that about 40% of overweight children will continue to have increased weight during adolescence and 75−80% of obese adolescents will become obese adults. A child with a high BMI has a high risk of being overweight or obese at 35 years of life and this risk increases with age. The consequences of this disease starting in childhood may be more severe as the duration of obesity will be longer. It may therefore have a greater deleterious impact on health and the rate of morbidity and mortality, than obesity starting in adulthood. Obesity results in several alterations that have been linked as co−morbidities of the disease. Hyperinsulinemia is prevalent in obesity and is strongly linked with cardiovascular disease, type 2 diabetes mellitus, hyperlipidemia, and hypertension. With few exceptions, the clinical features of cardiovascular heart disease are not apparent until the third or fourth decade of life. Therapeutic strategies to inhibit pigment epithelium derived factor action in muscle and liver, or prevent adipocyte PEDF release, may prove a viable approach to ameliorate obesity-induced insulin resistance and its associated pathologies |