الفهرس | Only 14 pages are availabe for public view |
Abstract n Systemic lupus erythematosus (SLE) is a chronic, immune-mediated disease in which T and B cells cause systemic tissue injury. SLE is characterized by the production of high levels of auto-antibodies against nuclear antigens, resulting, at least in part, from a dysregulated T lymphocyte response to autoantigens andthe immune system loses its ability to tell the difference between foreign substances and its own cells and tissue. The immune system then makes antibodies directed against “self”. This debilitating disease affects each patient differently. The objective of this study is to estimate the role of interferon gamma INFγin pediatric lupus nephritis and to estimate the role ofT regulatory cells (Treg cells) . For this purpose27 children with lupus nephritis were selected fromMansoura University Children’s Hospital (MUCH) to be investigated. The control group includes 11 healthy children. The results shows § There were significant increase in the mean levels of ESR, ANA, CRP and Anti-ds DNA in LN patients as compared to control group. § Hemoglobin and the frequency of peripheral blood INFγ %, CD8+ , CD4+CD25+ , CD4+CD25+ FOXP3+ T cells (%),obtained from LN patients were significantly decreased as compared to control group. Summary & Conclusion 87 § The frequencies of peripheral blood CD3+ , CD4+ , CD4+ /CD8+ T cells (%) of LN patients were significantly elevated as compared with control group. § The frequencies of urinary CD3+, CD4+ cells (%) were significantly elevated as compared with control group. But the frequency of urinary INFγ , CD8+ , were significantly reduced in control group as compared with LN group. In conclusion:The low expression of INFγ in T lymphocyte cells of LN patients may be a good marker in prognosis and diagnosis of LN.The decreased number of CD4+CD25+ and CD4+CD25+ FoxP3 T cells in the peripheral blood of pediatrics patients with LN constitutes a defective Treg population and contributes to the pathogenesis of LN. T cell subsets especially CD4+, and CD8+ T cells could play a central and pivotal role in the pathophysilogy of LN. |