الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Hemoglobinopathies are the group of genetic disorders of haemoglobin in which there is a quantitative or qualitative abnormal production or structure of haemoglobin molecule. B-Thalassemia is an inherited hemoglobin disorder caused by impaired synthesis of the b-globin chain and resulting in chronic hemolytic anemia. (Origa et al., 2017).Sickle cell disease (SCD) is a multisystem disease, associated with episodes of acute illness and progressive organ damage, and is one of the most common severe monogenic disorders worldwide (Inati et al., 2008; Rees et al.,2010; Piel et al.,2013). It is as much a disease of endothelial dysfunction as it is a hemoglobinopathy that triggers erythrocyte polymerization (Piel et al., 2017).