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Abstract Denture stomatitis is a common complication in patients wearing dentures and preventing the proliferation of related microorganisms and their induced infections is noteworthy. The aim of the present study was to assess the antimicrobial effect of acrylic resins containing 5% of silver nanoparticles, on Candida Albicans and the amount of silver released was calculated to detect its cytotoxic effect. For the Control group A: Ten specimens were prepared from pure PMMA. Experimental group B: Fifty specimens were prepared from PMMA containing 5 % of Ag NP. The samples were soaked in artificial saliva at interval period 3, 6, 9 months and the antimicrobial tests were performed at 0, 3, 6 and 9 months and compared with control group. Silver released in artificial saliva were measured by UVVis spectrophotometer instrument ”SHIMADZO UV-310 PC was using 1.0 cm and/or 0.2 cm matched silica cells. Mean and standard deviation were used to describe the data and one-way variance analysis test was performed to compare groups. Results: for control group A there was no inhibition zone for candida growth around the specimens. While for group B with Ag NP the greatest antimicrobial effect was found at immediate or zero time then was decreased gradually with increasing the time till reaching with no effect after 9 months resembling the control group. The amount of Nano silver in artificial saliva after 3 months was found to be little then it was increased gradually with increasing time. |