الفهرس 
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Abstract
Acne vulgaris is an inflammatory disease of the pilosebaceous unit of the skin that primarily involves the face and trunk and affects approximately 9% of the population worldwide. It can cause permanent physical scarring, negatively affect quality of life and self-image, and has been associated with increased rates of anxiety, depression, and suicidal ideation.
Asymmetric dimethylarginine (ADMA) plays a role in the regulation of L-arginine/nitric oxide (NO) pathway and is associated with endothelial dysfunction and oxidative stress. These have been shown to be important in the pathogenesis of many diseases.
Ischemia-modified albumin (IMA) is a new biochemical marker that is associated with ischemia, inflammation, and oxidative stress. High IMA levels have been determined in various inflammatory dermatological diseases such as psoriasis, alopecia areata, vitiligo, and Behçet’s disease.
Vitamin B6 is a water-soluble vitamin, which is the biologically active form and has been used clinically in the treatment of facial seborrheic dermatitis (FSD) for several decades. Vitamin B6 supplements have been linked to acne.
However, there are few studies examining IMA, ADMA and Vitamin B6 in acne vulgaris. Hence, we conducted this study to evaluate serum ADMA, IMA and Vitamin B6 in Patients with Acne Vulgaris to evaluate its role in the pathogenesis of the disease.
A prospective case control study was conducted during the period from February 2022 to June 2022 including 50 patients suffering from inflammatory and non-inflammatory Acne Vulgaris and 30 healthy controls attending the Dermatology Outpatient’s Clinic, Beni-Suef University Hospitals, Egypt according to inclusion and exclusion criteria.
All patients underwent full history taking, complete physical examination and investigations including estimation of serum levels of Asymmetric dimethylarginine (ADMA), Ischemia-modified albumin (IMA) and vitamin B6 using (ELISA) technique in both Acne Vulgaris patients and control groups using ELISA kits (Human Asymmetric dimethylarginine (ADMA) ELISA Kit, Human Ischemia Modified Albumin (IMA) and Vitamin B6 ELISA Kit).
We reported that positive family history was significantly more frequent among acne vulgaris patients than controls. there was no statistically significant difference between the studied groups as regard anthropometrics. ADMA, IMA and vitamin B6 were significantly higher in acne vulgaris cases than controls. Moreover, means of ADMA, IMA and vitamin B6 levels increased with the increase in disease severity with significant differences between the different severity groups.