الفهرس 
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Abstract
Acute poisoning is a common cause of admission to poison control centers which able to provide immediate, free, and expert treatment in cases of exposure to poisonous or hazardous substances and often needs treatment in the intensive care unit (ICU). It may occur either intentionally (deliberately) or unintentionally (accidentally).
A lot of poisons can cause hepatic affection in acute state as hydrogen cyanamide (dormex), organophosphorus nerve agents, drug overdose as paracetamol and valporic acid, aluminum phosphide and paraphenylinediamine.
Acute poisoning associated with hepatic impairment is very dangerous and may needs treatment in intensive care unit (ICU) because they may cause life-threatening complications that may result in death. There was an increasing rate of the number of cases of acute poisoning with hepatic affection arrived at Menoufia Poison and Dependence Control Center (MPDCC) throughout the last few years. So the present work aims to study the incidence of hepatic affection in acute poisoned cases admitted MPDCC over one year during the period from the (the 1st of June 2019) to (31th May 2020) regarding sociodemographic pattern, clinical presentation, investigations, poison severity score, treatment and outcome.
Patients, materials & methods
The data was collected from a previously designed clinical admission sheet as regarding sociodemographic pattern (age, sex, residence …etc), clinical presentation (symptoms and signs), investigations (laboratory and radiological when needed), classification of cases according to poison severity score (PSS) & its relation to treatment and outcome.
from the current study the following results can be concluded:
The incidence of hepatic affection during the period of the study was 2.14%. It shows that the most affected age group was ≤18 years (47.8%) followed by age group >25 years (34.8%) then age group >18-25 (17.4%). Regarding gender, it was found that males over numbered females (71.7% and 28.3% respectively). Cases from rural areas were more frequent than those from urban areas (82.6% and 18.4% respectively). The most affected categories were single.
Regarding the poison type, the highest percent was of dormex poisoning (58.7%), followed by pesticide (organophosphorus and aluminium phosphide) poisoning (21.7%), the least percent was of others (paracetamol, valporic acid & paraphenylinediamine) (19.6%).
The accidental mode of poisoning represented the high frequency than suicidal mode (58.7%, 41.3% respectively). No homicidal cases were reported. Regarding the poison data, the majority of the cases exposed to poison through skin route (54.3%), came to MPDCC within 3-6 hours of exposure (39.1%) and were not referred from other hospitals (47.8%).
Most of poisoning exposure occurred in winter and summer (67.4% and 30.4% respectively).
The most common patients’ complaints were disturbed level of consciousness (73.9%), followed by vomiting (39.1%), burn (19.6%), abdominal pain (13%), hoarseness and diarrhea (10.9%) for each.
Poison severity score was used to estimate the severity of the studied cases. The majority of cases were in moderate grade (47.8%) followed by cases of mild grade (28.3%) then the cases of severe grade (19.6%). The cases of fatal grade were (4.3%).