Search In this Thesis
   Search In this Thesis  
العنوان
Impact of Polyphenols Constituents of Fennel’s Seeds and Green Tea’s Leaves on some Biological Activities/
هيئة الاعداد
مشرف / Akmal Shawky Gaballa
مشرف / Yasser Abdel Aal Selim
مشرف / Akmal Shawky Rehab Ibrahem Tag Elden
مشرف / Esraa Abd Elfatah Awaad
الموضوع
feed
تاريخ النشر
2023.
عدد الصفحات
142p.:
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
اقتصاد منزلي
تاريخ الإجازة
1/1/2023
مكان الإجازة
جامعة الزقازيق - كلية التربية النوعية - تغذية وعلوم الاطعمة
الفهرس
Only 14 pages are availabe for public view

from 170

from 170

Abstract

Despite the huge advances in modern medicine, there are no completely effective drugs that provide complete protection for the body or help in cell regeneration. In addition, some drugs may induce hepatotoxicity. Therefore, it was necessary to find more effective and less toxic alternative drugs in the treatment of certain diseases.
from here came the idea of searching for alternatives to medicines to avoid their harmful effects. Therefore, the choice fell on two types of herbs that are the subject of this study, as these herbs are characterized by a pleasant taste and distinctive flavor, because they contain many chemical compounds, which were revealed through the analyzes conducted in this research.
The following has been done on both fennel seeds and green tea’s leaves:
1- Chemical study and nutritional value.
2- Chemical examination of plants.
3- HPLC analysis of polyphenols.
4- Biological study using white rats.
5- Biological activities (antioxidant and cytotoxic).
• The results of this study were divided into five sections:
• First: Chemical study:
Although vegetables contain a high percentage of nitrates, they were not chosen because they are affected by temperature and turn into toxic nitrosamines. Therefore, the seeds were chosen for their low fat content, in addition to their high protein and fiber content, which made them a healthy food.
And when fennel seeds were added with green tea leaves, their fat and moisture content were low, which helped in the long-term storage process.
• Second: Chemical examination of plants:
Fennel seeds and green tea leaves were chemically examined to detect their content of phenolic compounds. The results were as follows:
Fennel seeds contain 24% of phenolic compounds, steroids (a compound that has an anti-inflammatory role), and alkaloids (a source of nitrogen).
We also found that green tea leaves contain 68% of phenolic compounds, and coumarin (which acts as an inhibitor of arginine so that it does not turn into toxic nitrosamine).
• Third: HPLC analysis of phenolic compounds of fennel seeds and green tea leaves:
Through the analysis, we found that the most important compounds are caffeine, which is estimated at 37,741 in green tea leaves and is not found in fennel seeds, as well as apiginine is estimated at 85 in fennel seeds and is not found in green tea leaves, so the purpose of fortification was to reach the highest percentage of phenolic compounds To eliminate nitrosamine toxicity.
• Fourth: Biological study:
25 male albino mice were used, and they were divided from the beginning into two groups:
The first group: consisting of 5 mice that were negative controls were fed on basic food and water throughout the experiment for 30 days. The second group: consisted of 20 rats that were fed the basic food with the addition of 15% fat, 10% starch, and the rest of the quantity, which is 75% fodder. The infection occurred for a period of 15 days, and after confirming the high levels of sugar and fat in the blood, this group was divided into 4 subgroups, each group containing 5 rats, and they were as follows: group No. 2 was fed basic food with water for the rest of the experiment period. This group is called positive control and group No. 3 They were fed the basic food with fennel seeds added to it at a rate of 10% of the feed, and group No. 4 were fed the basic food with fennel seeds added with green tea leaves at a ratio of 9:1. group No. 5 were fed the basic food with fennel seeds added with green tea leaves. In a ratio of 4: 1, the effect of adding different proportions of fennel seeds and green tea leaves to the rats’ diet was measured compared to the infected, untreated group, and the results were as follows: With regard to weight gain, the highest values were in group No. The value of the average food intake ranged from 17.26 to 18.26, where the highest values were in group No. 4, those treated with a ratio of 9: 1 fennel seeds: green tea leaves. The food efficiency ratio was also calculated, where group 4 achieved the highest values.
• When measuring the percentage of cholesterol, triglycerides and glucose in
the blood, we found that group No. 4 treated with a ratio of 9: 1 recorded the best results compared to the control or negative group.
• Anatomy of the heart:
Through the natural vital processes that take place within the body, arginine is transformed into nitric oxide by the action of some enzymes, without excess or deficiency, because in both cases it represents a danger to the heart, so the best groups were treated with a ratio of 9: 1 because if the percentage of caffeine increased as in the group No. 5 The effect of this on the level of blood pressure in the body.