الفهرس 
ACUTE MYELOID LEUKEMIA (AML)Only 14 pages are availabe for public view
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Abstract
ABSTRACT
Introduction: Phospholipase D (PLD) enzymes have been implicated in diverse cellular processes in cancer, including the Warburg effect and pro-survival pathways. However, the significance of PLD’s role in tumorigenesis remains uncertain due to its genomic proximity to PI3Kinase-a, which is amplified in various cancers. Additionally, PLD signaling mechanisms are complex and context-dependent.
Objective: This study aimed to assess the level of PLD1 in newly diagnosed acute myeloid leukemia (AML) patients and its potential role as a prognostic marker.
Methods: A case-control study was conducted on 30 newly diagnosed AML patients and 30 age and sex-matched healthy controls. Serum samples were collected, and PLD1 levels were detected using ELISA. Correlations between PLD1 expression and clinical parameters were analyzed.
Results: A statistically significant increase in PLD1 level was observed in AML patients compared to healthy controls (p<0.0001).while there is no correlation between PLD1 ,survival rate and other prognostic markers.
Conclusion:. In conclusion, this research emphasizes the notable increase in serum PLD1level among AML patients and its connection with distinct FAB subtypes. Although certain clinical parameters displayed associations with PLD1, its direct influence on patient survival remains ambiguous, necessitating more extensive exploration with larger participant cohorts. The study significantly advances our comprehension of PLD1’s role in cancer biology and its potential as a promising prognostic indicator for AML.