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العنوان
Association between Ovarian reserve parameters and Thyroid disorders in Polycystic Ovary Syndrome /
هيئة الاعداد
باحث / اماني حمدي عبد السلام محمد
مشرف / عبد السميع عبد المنعم عبد السميع عبد المنعم
مشرف / محمد كمال خليل عتمان
مناقش / محمد كمال خليل عتمان
الموضوع
qrmak
تاريخ النشر
2022
عدد الصفحات
145 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
8/3/2022
مكان الإجازة
جامعة الفيوم - كلية الطب - امراض النسا والتوليد
الفهرس
Only 14 pages are availabe for public view

from 145

from 145

Abstract

PCOS is the most common endocrine disorder of reproductive- aged women and affects approximately 4 to 12 % in general population. It is associated with amenorrhea, infertility, hyperandrogenism, hyperinsulinemia, and metabolic syndrome. In patients affected by this disorder, it is important to make the appropriate diagnosis early and to closely monitor these individuals, as they may be at risk for other comorbidities as a consequence of the underlying pathology (Clark et al., 2015).
The term ”ovarian reserve” is used to describe the number and quality of oocytes in the ovary. Most of the known baseline ovarian reserve tests, apart from the antral follicle counts, provide an indirect reflection of the size of cohort of antral follicles. Anti-Müllerian Hormone (AMH) is involved in folliculogenesis and shows good correlation with chronological age, antral follicle counts and IVF outcome (Luesley and Baker, 2010).
As thyroid dysfunction may be associated with fertility problems, women with undiagnosed PCOS may often be referred to thyroid gland examination. Diseases causing overt hyperthyroidism or hypothyroidism can also induce menstrual disorders and fertility consequences. All receptors in the signaling pathway of thyroid hormone function including thyrotropin-releasing hormone (TRH), thyroid-stimulating hormone (TSH), and thyroid hormones were shown to be present in monkey uterus and influenced by long-term steroid hormone treatment (Hulchiy et al., 2012).
Pervin et al. (2020) evaluated and detected the thyroid dysfunction in patients with PCOS. They demonstrated that thyroid disorders are prevalent in 30.0% of PCOS patients. Hypothyroidism is almost three-fold more prevalent than hyperthyroidism. Wu et al. (2021) evaluated the relationship between the ovarian reserve, thyroid function, and AMH levels in infertile patients and found no significant correlation between the ovarian reserve and thyroid function-related indicators in women with infertility.