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Abstract
Background: Statins exert favorable effects on lipoprotein metabolism but may also possess anti-inflammatory effects. Several reports have described the ability of statins to suppress acute and chronic inflammation. Aim: The aim of the present work was to study the possible role of statins in improving bronchial hyperresponsiveness by possible anti-inflammatory, immune-modulatory or smooth muscle relaxant effects. This was conducted by comparison with dexamethasone and bambuterol in ovalbumin sensitized guinea pigs model of bronchial hyperresponsiveness