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Abstract
Objectives: evaluate the value of ascitic bacterial 16S rRNA gene determination in the rapid diagnosis of SBP. Results: 16s rRNA gene expression in ascitic fluid was positive in all 100 patients suspected to have SBP even in CNNNA, culture negative or patients had PMN < 250 cells/mm3. There was no correlation between 16s rRNA levels and the different laboratory parameters of our cases, it is only correlated with the results of ascitic fluid culture where its levels was higher in culture positive compared to those with culture negative. Conclusion: Identification of bacterial 16s rRNA in ascitic fluid has its significant clinical and diagnostic relevance in suspicion of SBP and its prompt therapy especially in CNNNA. It might be an alternative diagnostic tool to ascitic fluid bacterial culture and PMN in early diagnosis and prompt treatment with subsequent improvement of survival which needs further investigations