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Abstract Functional medical imaging is a non-invasive in-vivo diagnostic tool to investigate the abnormalities in the body organs. It is of a great clinical interest as it can detect or measure changes in metabolism and blood flow. As opposed to structural imaging, functional imaging focuses on revealing physiological activities within a certain tissue or organ. A lung perfusion scan is a nuclear medicine test that produces in a simple, non-invasive manner a picture of blood flow to the lungs and so used to detect pulmonary embolisms, determine how much blood is flowing to lungs and assess how well the lungs are functioning after surgery. It also can be used for diagnosis of lung cancer since patients with non-small cell lung cancer often have inhomogeneous lung perfusion |