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Abstract
This is a retrospective cohort study including previously untreated patients presented to National Cancer Institute, Cairo University with the diagnosis of LCH during the period 1/2008 {u2013} 6/2013. All biologic and epidemiologic data of the included patients were collected such as age, gender, race, the clinical, laboratory and radiological features, risk organs involved, risk stratification, different treatment protocols, outcome of treatment, prognostic factors& the effect of these factors on survival which were analyzed by disease free survival (DFS) and overall survival (OS)