الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by abnormal production of autoantibodies and pro - inflammatory cytokines. Although interleukin - 33 (IL - 33), a novel number of the IL - 1 family, has been reported to have proinflammatory effects, the association of IL - 33 with SLE and rheumatoid arthritis (RA) has remained unknown. The aim of this study is to examine whether the serum IL - 33 level is associated with SLE and RA. A total of 24 patients with SLE and 25 patients with RA were recruited. Sera from these patients were obtained at their visit and were compared to sera from 25 healthy controls for IL - 33 level. Furthermore, blood samples from patients with SLE were determined for various SLE - related and RA - related laboratory variables, including blood routine, complements, erythrocyte sedimentation rate (ESR) and C - reactive protein (CRP). Serum IL-33 level was significantly increased in patients with SLE, compared with healthy controls, and higher than that with RA