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Abstract
Aim: The aim of the present work was to investigate the possible role of growth hormone and simvastatin alone and combined on osteogenic bone changes induced by ovariectomy in rats. Furthermore, study the cardioprotective effects of each drug on myocardial ischemia induced by isoprenaline. Conclusion: It could be concluded from the present work that both growth hormone and simvastatin have antiosteoporotic effect as was evident by histopathological improvement in cortical and trabecular bone thickness more with simvastatin. The present study also demonstrated ischemic cardioprotective potential of growth hormone and simvastatin by attenuating isoprenaline- induced ST segment elevations, decreasing previously elevated heart rate, normalization of blood pressure alterations and improvement of altered histopathological changes of the heart tissue more with simvastatin