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Abstract
Objectives: This study aims at shedding light on possible answers for the following questions: 1-Can mesenchymal stem cells home in the ovaries of both control and chemotherapy treated animals. 2-Is there a possible role of TNF-Ü in homing of stem cells. 3-If they home, do they produce their effect through differentiation into follicles themselves or through secretion of some growth factors such as IGF-I. Conclusion: Injected bone marrow derived MSCs can migrate and home in the stroma of the injured ovaries, with gradual partial improvement of hormonal function, follicular number, maturation and architecture of ovaries damaged by cyclophosphamide. IGF-I can play a role in such improvement after stem cells injection in chemotherapy- induced ovarian failure. Elevated ovarian TNF- Ü levels may have a role in migration and attraction of stem cells in vivo